WO1995018606A1 - Curcumin, analogues of curcumin and novel uses thereof - Google Patents
Curcumin, analogues of curcumin and novel uses thereof Download PDFInfo
- Publication number
- WO1995018606A1 WO1995018606A1 PCT/US1995/000104 US9500104W WO9518606A1 WO 1995018606 A1 WO1995018606 A1 WO 1995018606A1 US 9500104 W US9500104 W US 9500104W WO 9518606 A1 WO9518606 A1 WO 9518606A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sep
- acid
- curcumin
- cells
- cell
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU15585/95A AU687509B2 (en) | 1994-01-06 | 1995-01-05 | Curcumin, analogues of curcumin and novel uses thereof |
EP95907307A EP0738143A1 (en) | 1994-01-06 | 1995-01-05 | Curcumin, analogues of curcumin and novel uses thereof |
JP7518587A JPH10500657A (ja) | 1994-01-06 | 1995-01-05 | クルクミン、クルクミン類似体、およびそれらの新しい使用法 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17803394A | 1994-01-06 | 1994-01-06 | |
US08/178,033 | 1994-01-06 | ||
US19808894A | 1994-02-17 | 1994-02-17 | |
US08/198,088 | 1994-02-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1995018606A1 true WO1995018606A1 (en) | 1995-07-13 |
WO1995018606A9 WO1995018606A9 (en) | 1997-05-22 |
Family
ID=26873885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/000104 WO1995018606A1 (en) | 1994-01-06 | 1995-01-05 | Curcumin, analogues of curcumin and novel uses thereof |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0738143A1 (ja) |
JP (1) | JPH10500657A (ja) |
AU (1) | AU687509B2 (ja) |
CA (1) | CA2180477A1 (ja) |
IL (1) | IL112205A0 (ja) |
WO (1) | WO1995018606A1 (ja) |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0833629A2 (en) * | 1995-06-19 | 1998-04-08 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
EP1027045A1 (en) * | 1997-10-31 | 2000-08-16 | Arch Development Corporation | Methods and compositions for regulation of 5-alpha reductase activity |
WO2000047205A1 (en) * | 1999-02-10 | 2000-08-17 | The Trustees Of The University Of Pennsylvania | Tyrosine kinase inhibitors and methods of using the same |
WO2000061162A1 (en) * | 1999-04-09 | 2000-10-19 | Sabinsa Corporation | Use of tetrahydrocurcuminoids to regulate physiological and pathological events in the skin and mucosa |
WO2000070949A1 (en) * | 1999-05-20 | 2000-11-30 | Heng Madalene C Y | Method for using soluble curcumin to inhibit phosphorylase kinase in inflammatory diseases |
WO2001000201A1 (en) * | 1999-06-30 | 2001-01-04 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
DE10029770A1 (de) * | 2000-06-16 | 2001-12-20 | Transmit Technologietransfer | Verwendung von Curcuminen zur Behandlung von soliden Tumoren,insbesondere von Hirntumoren |
WO2002002582A1 (de) * | 2000-06-30 | 2002-01-10 | Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts | Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel |
DE19821971C2 (de) * | 1998-05-18 | 2003-02-06 | Ulti Med Products Deutschland | Arzneimittel zur Behandlung von Psoriasis oder Neurodermitis |
US6653327B2 (en) | 1999-04-09 | 2003-11-25 | Sabinsa Corporation | Cross-regulin composition of tumeric-derived tetrahydrocurcuminoids for skin lightening and protection against UVB rays |
EP1411959A1 (en) * | 2001-07-17 | 2004-04-28 | Metaproteomics, LLC | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 |
US6740665B1 (en) | 1999-02-10 | 2004-05-25 | Ramachandran Murali | Tyrosine kinase inhibitors and methods of using the same |
EP1494993A2 (en) * | 2002-04-17 | 2005-01-12 | University Of North Carolina At Chapel Hill | Novel curcumin analogues and uses thereof |
WO2006087759A2 (en) * | 2005-02-21 | 2006-08-24 | Safi Investment Holding Ag | Pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field |
EP1694335A2 (en) * | 2003-08-26 | 2006-08-30 | Research Development Foundation | Osteoclastogenesis inhibitors and uses thereof |
WO2006097744A2 (en) * | 2005-03-17 | 2006-09-21 | Imperial Innovations Limited | Phenol derivatives and their use to modulate pkb activity |
WO2007098504A1 (en) * | 2006-02-24 | 2007-08-30 | Emory University | Prodrugs of curcumin analogs |
WO2007112855A1 (en) * | 2006-03-30 | 2007-10-11 | Unilever Plc | Skin lightening agents, compositions and methods |
US7355081B2 (en) | 2002-04-17 | 2008-04-08 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
WO2009073050A2 (en) * | 2007-07-27 | 2009-06-11 | Research Foundation Of City University Of New York | Use of curcumin to block brain tumor formation in vivo |
WO2009101263A2 (en) * | 2008-02-15 | 2009-08-20 | Novobion Oy | Soluble complexes of curcumin |
EP2359820A1 (en) | 2010-01-29 | 2011-08-24 | Codman & Shurtleff, Inc. | Shunt delivery of curcumin for the treatment Alzneimer |
AU2007234455B2 (en) * | 2006-03-31 | 2012-10-04 | The Board Of Regents Of The University Of Texas System | Orally bioavailable caffeic acid related anticancer drugs |
US8383865B2 (en) | 2007-04-17 | 2013-02-26 | Codman & Shurtleff, Inc. | Curcumin derivatives |
US8637675B2 (en) | 2008-07-08 | 2014-01-28 | Board Of Regents, The University Of Texas System | Inhibitors of proliferation and activation of signal transducer and activators of transcription (STATS) |
US8647681B2 (en) | 2001-06-01 | 2014-02-11 | Mars, Inc. | Skin diet |
US8648102B2 (en) | 2003-12-11 | 2014-02-11 | Board Of Regents, The University Of Texas System | Compounds for treatment of cell proliferative diseases |
EP2749552A1 (en) | 2007-04-17 | 2014-07-02 | Codman & Shurtleff, Inc. | Curcumin-resveratrol hybrids |
CN105669788A (zh) * | 2016-03-18 | 2016-06-15 | 昆明理工大学 | 一种从竹笋中提取活性化合物的方法及其应用 |
WO2020239948A1 (en) | 2019-05-28 | 2020-12-03 | Isanas Ag | A CENTRALLY ACTING µ-OPIOID RECEPTOR AGONIST IN COMBINATION WITH A CURCUMINOID FOR USE IN THE TREATMENT OF A TUMOUR OF THE CENTRAL NERVOUS SYSTEM |
US10875841B2 (en) | 2018-08-29 | 2020-12-29 | Baylor College Of Medicine | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents |
US11312676B2 (en) | 2014-12-30 | 2022-04-26 | Baylor College Of Medicine | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003090681A2 (en) * | 2002-04-24 | 2003-11-06 | Research Development Foundation | SYNERGISTIC EFFECTS OF NUCLEAR TRANSCRIPTION FACTOR NF-κB INHIBITORS AND ANTI-NEOPLASTIC AGENTS |
CN116407527A (zh) * | 2023-01-04 | 2023-07-11 | 河南科技大学第一附属医院 | 咖啡酸的应用以及用于预防和治疗口腔鳞癌的药物 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3777037A (en) * | 1970-09-22 | 1973-12-04 | Us Agriculture | Cinnamyl phenols useful as anti-microbial agents |
JPS5045660A (ja) * | 1973-08-25 | 1975-04-23 | ||
JPS57185219A (en) * | 1981-05-12 | 1982-11-15 | Chugai Pharmaceut Co Ltd | Remedy for cancer |
US4421927A (en) * | 1980-10-23 | 1983-12-20 | Societe De Recherches Industrielles (S.O.R.I.) | New cinnamoyl-cinnamic acid derivative, and its use as pharmaceutical |
US4733002A (en) * | 1984-05-23 | 1988-03-22 | Green Cross Corporation | Lipoxygenase inhibitor |
US4842859A (en) * | 1986-09-08 | 1989-06-27 | Yaguang Liu | Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation |
US4904697A (en) * | 1987-04-09 | 1990-02-27 | Merrell Dow Pharmaceuticals Inc. | Controlling the growth of certain tumor tissue with chalcone derivatives |
US5120538A (en) * | 1990-02-05 | 1992-06-09 | Pt Darya-Varia Laboratoria | Combinations of compounds isolated from curcuma spp as anti-inflammatory agents |
US5216024A (en) * | 1987-07-28 | 1993-06-01 | Baylor College Of Medicine | Cell growth inhibitors and methods of treating cancer and cell proliferative diseases |
US5238832A (en) * | 1992-06-08 | 1993-08-24 | Board Of Governors Of Wayne State University | Aryl aliphatic acids |
US5288750A (en) * | 1988-09-01 | 1994-02-22 | Orion-Yhtyma Oy | Substituted β-diketones |
-
1994
- 1994-12-30 IL IL11220594A patent/IL112205A0/xx unknown
-
1995
- 1995-01-05 AU AU15585/95A patent/AU687509B2/en not_active Ceased
- 1995-01-05 WO PCT/US1995/000104 patent/WO1995018606A1/en not_active Application Discontinuation
- 1995-01-05 JP JP7518587A patent/JPH10500657A/ja active Pending
- 1995-01-05 EP EP95907307A patent/EP0738143A1/en not_active Withdrawn
- 1995-01-05 CA CA002180477A patent/CA2180477A1/en not_active Abandoned
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3777037A (en) * | 1970-09-22 | 1973-12-04 | Us Agriculture | Cinnamyl phenols useful as anti-microbial agents |
JPS5045660A (ja) * | 1973-08-25 | 1975-04-23 | ||
US4421927A (en) * | 1980-10-23 | 1983-12-20 | Societe De Recherches Industrielles (S.O.R.I.) | New cinnamoyl-cinnamic acid derivative, and its use as pharmaceutical |
JPS57185219A (en) * | 1981-05-12 | 1982-11-15 | Chugai Pharmaceut Co Ltd | Remedy for cancer |
US4733002A (en) * | 1984-05-23 | 1988-03-22 | Green Cross Corporation | Lipoxygenase inhibitor |
US4842859A (en) * | 1986-09-08 | 1989-06-27 | Yaguang Liu | Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation |
US4904697A (en) * | 1987-04-09 | 1990-02-27 | Merrell Dow Pharmaceuticals Inc. | Controlling the growth of certain tumor tissue with chalcone derivatives |
US5216024A (en) * | 1987-07-28 | 1993-06-01 | Baylor College Of Medicine | Cell growth inhibitors and methods of treating cancer and cell proliferative diseases |
US5288750A (en) * | 1988-09-01 | 1994-02-22 | Orion-Yhtyma Oy | Substituted β-diketones |
US5120538A (en) * | 1990-02-05 | 1992-06-09 | Pt Darya-Varia Laboratoria | Combinations of compounds isolated from curcuma spp as anti-inflammatory agents |
US5238832A (en) * | 1992-06-08 | 1993-08-24 | Board Of Governors Of Wayne State University | Aryl aliphatic acids |
Non-Patent Citations (6)
Cited By (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0833629A4 (en) * | 1995-06-19 | 1998-09-16 | Ontogen Corp | ARYL-ACRYLIC ACID DERIVATIVES SUITABLE AS PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS |
EP0833629A2 (en) * | 1995-06-19 | 1998-04-08 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
EP1027045A1 (en) * | 1997-10-31 | 2000-08-16 | Arch Development Corporation | Methods and compositions for regulation of 5-alpha reductase activity |
EP1027045A4 (en) * | 1997-10-31 | 2004-12-08 | Arch Dev Corp | METHODS AND COMPOSITIONS FOR REGULATING 5-ALPHA-REDUCTASE ACTIVITY |
DE19821971C2 (de) * | 1998-05-18 | 2003-02-06 | Ulti Med Products Deutschland | Arzneimittel zur Behandlung von Psoriasis oder Neurodermitis |
WO2000047205A1 (en) * | 1999-02-10 | 2000-08-17 | The Trustees Of The University Of Pennsylvania | Tyrosine kinase inhibitors and methods of using the same |
US6740665B1 (en) | 1999-02-10 | 2004-05-25 | Ramachandran Murali | Tyrosine kinase inhibitors and methods of using the same |
WO2000061162A1 (en) * | 1999-04-09 | 2000-10-19 | Sabinsa Corporation | Use of tetrahydrocurcuminoids to regulate physiological and pathological events in the skin and mucosa |
US6653327B2 (en) | 1999-04-09 | 2003-11-25 | Sabinsa Corporation | Cross-regulin composition of tumeric-derived tetrahydrocurcuminoids for skin lightening and protection against UVB rays |
WO2000070949A1 (en) * | 1999-05-20 | 2000-11-30 | Heng Madalene C Y | Method for using soluble curcumin to inhibit phosphorylase kinase in inflammatory diseases |
US6673843B2 (en) * | 1999-06-30 | 2004-01-06 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
EP1196158A1 (en) * | 1999-06-30 | 2002-04-17 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
EP1196158A4 (en) * | 1999-06-30 | 2004-05-26 | Univ Emory | INHIBITION OF ANGIOGENESIS THROUGH THE USE OF CURCUMIN AND CURCUMINOIDS |
WO2001000201A1 (en) * | 1999-06-30 | 2001-01-04 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
DE10029770A1 (de) * | 2000-06-16 | 2001-12-20 | Transmit Technologietransfer | Verwendung von Curcuminen zur Behandlung von soliden Tumoren,insbesondere von Hirntumoren |
WO2002002582A1 (de) * | 2000-06-30 | 2002-01-10 | Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts | Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel |
US8647681B2 (en) | 2001-06-01 | 2014-02-11 | Mars, Inc. | Skin diet |
EP1411959A4 (en) * | 2001-07-17 | 2007-12-19 | Metaproteomics Llc | CURCUMINOID COMPOSITIONS WITH SYNERGISTIC INHIBITION OF THE EXPRESSION AND / OR ACTIVITY OF CYCLOOXYGENASE-2 |
EP1411959A1 (en) * | 2001-07-17 | 2004-04-28 | Metaproteomics, LLC | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 |
US7355081B2 (en) | 2002-04-17 | 2008-04-08 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
US8198323B2 (en) | 2002-04-17 | 2012-06-12 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
EP1494993A2 (en) * | 2002-04-17 | 2005-01-12 | University Of North Carolina At Chapel Hill | Novel curcumin analogues and uses thereof |
EP1494993A4 (en) * | 2002-04-17 | 2005-09-14 | Univ North Carolina | NEW CURCUMINALOGA AND ITS APPLICATIONS |
AU2003222087B2 (en) * | 2002-04-17 | 2008-08-21 | University Of North Carolina At Chapel Hill | Novel curcumin analogues and uses thereof |
AU2003222087B8 (en) * | 2002-04-17 | 2008-09-04 | University Of North Carolina At Chapel Hill | Novel curcumin analogues and uses thereof |
US7709535B2 (en) | 2003-03-27 | 2010-05-04 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
EP1694335A4 (en) * | 2003-08-26 | 2008-12-31 | Res Dev Foundation | OSTEOCLASTOGENESIS HEMMER AND ITS USES |
EP1694335A2 (en) * | 2003-08-26 | 2006-08-30 | Research Development Foundation | Osteoclastogenesis inhibitors and uses thereof |
US8648102B2 (en) | 2003-12-11 | 2014-02-11 | Board Of Regents, The University Of Texas System | Compounds for treatment of cell proliferative diseases |
US9096499B2 (en) | 2003-12-11 | 2015-08-04 | Board Of Regents, The University Of Texas System | Compounds for treatment of cell proliferative diseases |
WO2006087759A3 (en) * | 2005-02-21 | 2007-02-08 | Safi Invest Holding Ag | Pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field |
WO2006087759A2 (en) * | 2005-02-21 | 2006-08-24 | Safi Investment Holding Ag | Pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field |
WO2006097744A3 (en) * | 2005-03-17 | 2007-02-01 | Imp Innovations Ltd | Phenol derivatives and their use to modulate pkb activity |
WO2006097744A2 (en) * | 2005-03-17 | 2006-09-21 | Imperial Innovations Limited | Phenol derivatives and their use to modulate pkb activity |
WO2007098504A1 (en) * | 2006-02-24 | 2007-08-30 | Emory University | Prodrugs of curcumin analogs |
KR101390058B1 (ko) | 2006-03-30 | 2014-04-29 | 유니레버 엔.브이. | 피부 미백제, 조성물 및 방법 |
WO2007112855A1 (en) * | 2006-03-30 | 2007-10-11 | Unilever Plc | Skin lightening agents, compositions and methods |
AU2007234455B2 (en) * | 2006-03-31 | 2012-10-04 | The Board Of Regents Of The University Of Texas System | Orally bioavailable caffeic acid related anticancer drugs |
US8779151B2 (en) | 2006-03-31 | 2014-07-15 | The Board Of Regents Of The University Of Texas System | Orally bioavailable caffeic acid related anticancer drugs |
EP2749552A1 (en) | 2007-04-17 | 2014-07-02 | Codman & Shurtleff, Inc. | Curcumin-resveratrol hybrids |
US8383865B2 (en) | 2007-04-17 | 2013-02-26 | Codman & Shurtleff, Inc. | Curcumin derivatives |
WO2009073050A2 (en) * | 2007-07-27 | 2009-06-11 | Research Foundation Of City University Of New York | Use of curcumin to block brain tumor formation in vivo |
WO2009073050A3 (en) * | 2007-07-27 | 2009-10-01 | Research Foundation Of City University Of New York | Use of curcumin to block brain tumor formation in vivo |
WO2009101263A2 (en) * | 2008-02-15 | 2009-08-20 | Novobion Oy | Soluble complexes of curcumin |
US8568815B2 (en) | 2008-02-15 | 2013-10-29 | Novobion Oy | Soluble complexes of curcumin |
WO2009101263A3 (en) * | 2008-02-15 | 2009-10-15 | Novobion Oy | Soluble complexes of curcumin |
US8637675B2 (en) | 2008-07-08 | 2014-01-28 | Board Of Regents, The University Of Texas System | Inhibitors of proliferation and activation of signal transducer and activators of transcription (STATS) |
US9000179B2 (en) | 2008-07-08 | 2015-04-07 | Board Of Regents, The University Of Texas System | Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs) |
EP2359820A1 (en) | 2010-01-29 | 2011-08-24 | Codman & Shurtleff, Inc. | Shunt delivery of curcumin for the treatment Alzneimer |
US11312676B2 (en) | 2014-12-30 | 2022-04-26 | Baylor College Of Medicine | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer |
CN105669788A (zh) * | 2016-03-18 | 2016-06-15 | 昆明理工大学 | 一种从竹笋中提取活性化合物的方法及其应用 |
US10875841B2 (en) | 2018-08-29 | 2020-12-29 | Baylor College Of Medicine | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents |
US11708350B2 (en) | 2018-08-29 | 2023-07-25 | Baylor College Of Medicine | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents |
WO2020239948A1 (en) | 2019-05-28 | 2020-12-03 | Isanas Ag | A CENTRALLY ACTING µ-OPIOID RECEPTOR AGONIST IN COMBINATION WITH A CURCUMINOID FOR USE IN THE TREATMENT OF A TUMOUR OF THE CENTRAL NERVOUS SYSTEM |
Also Published As
Publication number | Publication date |
---|---|
AU687509B2 (en) | 1998-02-26 |
IL112205A0 (en) | 1995-03-15 |
JPH10500657A (ja) | 1998-01-20 |
CA2180477A1 (en) | 1995-07-13 |
AU1558595A (en) | 1995-08-01 |
EP0738143A1 (en) | 1996-10-23 |
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